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Published:
Mar 25, 2024DOI:
10.4314/gmj.v58i1.8Keywords:
Article Details
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Main Article Content
Sex hormone-binding globulin is a valuable diagnostic indicator of gestational diabetes mellitus
Abstract
Objective: To assess the performance of the Sex Hormone-Binding Globulin (SHBG) assay as a diagnostic indicator of Gestational Diabetes Mellitus (GDM) in the study population.
Design: Analytical cross-sectional study
Setting: Hospital-based, Benue State University Teaching Hospital (BSUTH), Makurdi, Nigeria.
Participants: Women with singleton pregnancies at 24 to 28 weeks gestational age attending Antenatal care at BSUTH, Makurdi.
Intervention: Serum SHBG levels were assayed by ELISA during a diagnostic 75-gram Oral Glucose Tolerance Test (OGTT) for assessment of GDM in the cohort of consecutively selected participants who met the inclusion criteria.
Main Outcome Measures: Serum levels of SHBG and presence of GDM in the participants.
Result: Serum SHBG was significantly negatively correlated (rpb = - 0.534, p-value < 0.001) with the presence of GDM. It had an area under the ROC curve of 0.897 (95% Confidence Interval = 0.858–0.935; p-value < 0.001). A cut-off value of 452.0 nmol/L indicative of GDM had a diagnostic odds ratio of 21.4 in the study population.
Conclusion: SHBG is a valuable diagnostic indicator for GDM in the study population.
