The Effect Of Larimal® Administration On Nissl Substances Distribution In The Cerebellum Of Wistar Rats

Abstract

Larimal® is an artemisinin base antimalarial drug made up of amodiaquine and artesunate. Thus the effect of this drug on Nissl substances distribution in the cerebellum of Wistar rats was carried out. Twenty adult Wistar rats were divided equally into four groups. Group 1 served as the control and the animals received distilled water, while groups 2, 3 and 4 were the experimental groups and the animals were treated with 17.50mg/kg+5.71mg/kg, 8.75mg/kg+2.86mg/kg and 8.75mg/kg+2.86mg/kg of Larimal® respectively. The administration lasted three days for groups 2 and 3, and six days of group 4. Nissl substances staining were reduced in groups 2 and 4 compared to groups 1 and 3. This
indicates chromatolysis in groups 2 and 4, a result of tissue toxicity. This result reveals that increase dose and duration of Larimal® is toxic to cerebellar tissues which may likely result in cerebellar dysfunction.