Durational exposure-dependent effect of carbamate treated net on hepatic and renal functions in Wistar rats

Abstract

Assessment of the duration exposure-dependent effect of carbamate treated net on hepatic and renal functions of albino Wistar rats after 30 and 60 days was carried out. Serum ALT, AST and ALP levels were determined to assess liver function while serum creatinine and urea levels were measured for kidney function. Eighteen (18) male albino Wstar rats weighing 138-146g were divided into 3 groups of 6 rats each. Group 1 served as control, group 2 animals were exposed to carbamate treated net for 30 days and group 3 animals exposed for 60 days. The results showed that the levels of serum AST and ALT increased in all the experimental groups exposed when compared to the control group. ALT increased significantly (p<0.05) in the rats exposed for 60 days (203.83±0.307) while AST increased highest in experimental groups exposed for 30 days (203± 1.613)and 60 days (362± 0.365) respectively when compared to the control (150.5±0.34). ALP increased significantly (p<0.05) only in the group exposed for 30 days (17.67±0.21),but decreased in the group exposed for 60 days when compared to the control group. Serum creatinine increased insignificantly (p>0.05) in the group exposed for 30 days but decreased in the group exposed for 60 days while serum urea level in the group exposed for 30 days remain unchanged but decreased after 60 days when compared to the control group. Statistically, there was a significant increase (p<0.05) in body weight and organ weight of the animals exposed for 30 and 60 days. Therefore, this present study demonstrates that exposure to carbamate treated net may alter the integrity and function of liver thereby causing hepatotoxicity while the exposure of rats to carbamate treated net may not pose any significant nephrotoxicity in rats.