Durational exposure dependent effect of carbamate treated net on haematological indices in wistar rat

Abstract

The present study was undertaken to investigate the duration of exposure dependent effect of carbamate treated net on haematological indices in Wistar rats. Eighteen (18) Wistar rats were used in this study and designated into three (3) study groups of six rats each. Group 1 was the control group while groups 2 and 3 constituted the experimental groups containing rats exposed to carbamate treated net for 30 and 60 days respectively. At the end of the exposure period, the animals were sacrificed and blood sample were removed for haematological analysis. The result of the study shows that there was a significant increase in the body weight of exposed rats compared to rats in the control group at (P<0.05). Relative organ weight of the exposed rats increased significantly (p<0.05) when compared to rats in the control group. The PCV, Hb, RBC’s, PLT, MCV, MCH, and MCHC levels all increased insignificantly in the exposed rats when compared to rats in the control group at (p<0.05). The study also revealed that the total White Blood Cell (WBC) counts in the exposed groups was significantly elevated when compared to the control group at (P<0.05). Finally, the result of the study shows a significant increase (p<0.05) in the levels of neutrophil of the exposed rats when compared with the control group, while the level of lymphocytes, eosinophils and monocytes increased insignificantly (p>0.05) in rats exposed for 30 days but increased significantly (p<0.05) in rats exposed for 60 days when compared to rats in their control group. Therefore, the observation from this study suggests that long-term exposure to carbamate treated net may alter the haematological indices and hence lead to various health problem.

Keywords: Body Weight, Carbamate, Organs Weight and Heamatological Indices