Investigations Of Powder Surface Properties Of Drug Substances Using Inverse Gas Chromatography (IGC)

Abstract

In this study, Inverse Gas Chromatography (IGC) was used to characterize the surface energetics of different batches of two drug substances (Salmetrol Xinafoate, SX and Fluticasone Propionate, FP) manufactured under identical conditions. The results obtained demonstrate the potential of IGC technique to reveal batch-to-batch variability of these drugs. It is shown that the surface energy differences detected by IGC can be ascribed to secondary processing operations such as milling, micronisation and, or blending. This technique in practice therefore, provided an assurance of the same surface energy between batches of materials and eliminates the batches which may ultimately affect the quality and performance of the final products.

Keywords: Gas Chromatography, Dispersive Energy, Acid/base Probe molecules.

Global Journal or Pure and Applied Sciences Vol. 14 (4) 2008: pp. 407-410