Hepatoprotective Effect Of Sephadex G50 Red Fraction Of H. Rosasinensis Petal Anthocyanin Administered To Rats In Ethanol

Abstract

The hepatoprotective effects of the two sephadex G50 fractions of the anthocyanin obtained from the petals of H. rosainensis were studied. Treatment of rats with 8.40 g of the red fraction (G50 RF) in 5% aqueous ethanol/kg body weight 5 days/week for 4 weeks before carbon tetrachloride resulted in significantly (P<0.05) less hepatotoxicity than with carbon tetrachloride alone, as measured by plasma L-alanine aminotransferase activity and liver malondialdehyde levels 18 hr after carbon tetrachloride. When similar treatment was given to rats using the second fraction, the purple fraction (G50 PF) there was no significant (P>0.05) decrease in hepatotoxicity relative to those treated with carbon tetrachloride alone. These data suggest that it is the red rather than the purple pigment of H. rosasinensis anthocyanin that is protective against carbon tetrachloride-induced liver injury.

Key Words: Anthocyanin; G50RF; G50PF; Hepatotoxicity; Carbon tetrachloride


(Global Journal of Pure and Applied Sciences: 2002 8(2): 259-264)