Anti malarial drug quinine and activated charcoal effect on hAematological parameters in rats.

Abstract

The efficacy of oral administration of activated charcoal in ameliorating the harmful effect of quinine on haematological parameters- packed cell volume (PCV), haemoglobin concentration (Hb) and erythrocyte count (Rbc) in animal model was studied. Quinine alone (P <0.05) or activated charcoal alone (P < 0.01) significantly reduced the parameters studied compared with control. Although there was no significant difference in the values of the parameters studied when activated charcoal was administered 10 minutes before or after oral ingestion of quinine hitherto the reduction in the values of PCV,Hb and Rbc were similar to that obtained with activated charcoal alone; which suggests that oral administration of activated charcoal as early as possible may have a beneficial effect in reducing the toxicological effects of quinine on blood parameters.

Key words: Blood picture; charcoal-therapeutic-use; quinine, animal.


(Global Journal of Pure and Applied Sciences: 2002 9(1): 39-42)