Effect of thermoxidised groundnut oil on aminotransferase activity of heart tissue in wistar rats

Abstract

The effect of thermoxidised groundnut oil on the aminotransferase activity of the heart health of Wistar rats was investigated. Eighteen female albino rats were randomly divided into three groups of six rats each .Group 1 was fed 15% fresh groundnut oil supplemented rat pellet, group 2 received 15% thermoxidised groundnut oil supplemented rat pellet, while group 3 received the normal pellet only. The feeding experiment lasted for a period of twenty one days after which the animals were sacrificed and tissue homogenates analyzed for tissue enzymes using standard methods. The results indicated a significant increase (P<0.05) concentrations of alanine aminotransferase (ALT) in animals treated with the oils with respect to the control. The AST showed similar pattern in group 2 treated when compared to the control. The amongst group variation was not significant. We therefore conclude that thermoxidised groundnut oil impact adversely on heart tissues as indicated in raised enzyme levels.

KEYWORDS: Wistar rats, groundnut oil, thermoxidation and aminotransferase