Some physical properties of theophylline monohydrate Sustained Release Tablets formulated with Abelmoschus esculentus Gum as a Hydrophilic Matrix

Abstract

Abelmoschus esculentus (okro) gum remarkably prolonged/delayed the release of theophylline monohydrate from the sustained release tablets. It performed better than ethyl cellulose and much better than gelatin as a sustained release drug matrix. It is very effective at low concentrations. The kinetics of drug release changed from first order to Higuchi diffusion controlled as the polymer concentrations increased from 2-10% w/w.


KEY WORDS: Sustained release, Abelmoschus esculentus, Hydrophilic matrix


Global Jnl Medical Sciences Vol.2(2) 2003: 145-152