PROFILE OF SERUM LIVER ENZYMES OF WISTAR ALBINO RATS FOLLOWING ACUTE ORAL ADMINISTRATION OF A DRUG COLOURANT, BRIGHT RED.

Abstract

The acute in-vivo effect of oral administration of the drug colourant, Bright Red was investigated. Three groups of rats were administered 500mg, 1000mg and 2000mg per Kg body weight of the colourant daily consecutive for three days. The control group was given sham treatment with equivalent volume of distilled water. The effects of the colourant on serum-liver levels of aspartate aminotransferase (EC 2.6.1.1) and alkaline phosphatase (EC 3.1.3.1) were compared with the control group, which received only the diluent for the administration of the test colourant solution. The serum and liver levels of aspartate aminotransferase (AST) and alkaline phosphatase (ALP) increased in a dose related manner. The serum-liver enzymes showed significant elevations (P< 0.05) in the three test groups compared to the control group. The results indicate that acute oral administration of Bright Red colourant could be injurious to liver cell integrity.


Key words: Drug colourant, Bright Red, alkaline phosphatase, aspartate aminotransferase, Liver.


(Global J Med Sci: 2002 1(1): 29-34)