Seroprevalence and associated risk factors of Toxoplasma gondii infection in immuno-compromised women and sheep of Bahir Dar City, Ethiopia

Abstract

Toxoplasmosis is one of the most significant worldwide zoonotic infections caused by the protozoan parasite Toxoplasma gondii. It is a major public health and veterinary concern in terms of mortality and morbidity. The objective of this study was to estimate the seroprevalence and assess the potential risk factors of T. gondii infection among pregnant women, HIV/AIDS patients, and sheep in Bahir Dar city, North West Ethiopia. A cross-sectional study design and systematic random sampling techniques were employed. Serum samples were analyzed for anti-T. gondii antibodies using a commercially available Toxo-latex agglutination test kit. Logistic regression analysis was employed to test associations between variables. The seroprevalences of T. gondii infection in the examined pregnant women, HIV/AIDS patients, and sheep were 70.8% (95% confidence interval (CI): 65.1-73.4%), 70% (95% CI: 63.3-76.8%), and 43% (95% CI: 38.5 - 47.4%) respectively. Multivariable logistic analysis showed that T. gondii infection was significantly associated with knowing the zoonotic nature of toxoplasmosis (adjusted Odds ratio [AOR] = 0.197, 95% confidence interval [CI]: 0.107 - 0.35), eating raw meat (AOR=3.27, 95% CI: 1.89-5.65), and owning a cat (AOR=9.35, 95% CI: 4.00-21.84) in pregnant women and HIV/ AIDS patients. Hence, comprehensive health education about toxoplasmosis, particularly for pregnant women and HIV/AIDS patients, avoiding consumption of uncooked meat, and cat contact for immune-compromised women are of paramount importance.