Antihyperglycaemic, Antilipidperoxidative and Antioxidative Effects of Extracts of Musa paradisiaca and Coccinia indica in Streptozotocin-Induced Diabetic Rat

Abstract

The present study was conducted to evaluate the antihyperglycaemic, antihyperlipidemic and antioxidative effects of aqueous methanolic extracts of the root of Musa paradisiaca and the leaves of Coccinia indica separately as well as in composite manner, in streptozotocin-(STZ) induced diabetic male albino rats. The results revealed that co-administration of the composite extract of the above plant parts to STZ-treated rats,
reversed the levels of fasting blood glucose, serum insulin and glycosylated haemoglobin (GHb) towards the control level. Lipid peroxidation indicators such as serum levels of total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol (LDLc), very low density lipoprotein cholesterol (VLDLc), high density lipoprotein cholesterol (HDLc) and the activities of catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) as well as the levels of conjugated diene (CD) and thiobarbituric acid reactive substance (TBARS) in liver and kidney, were also shifted towards the control level in composite
extract co-administered STZ-induced diabetic rats. Although extracts of the individual plants showed activity when administered separately, their effect was much more pronounced when they were administered together. This study highlighted the potentials of these herbs in type I diabetes.

Keywords: antihyperglycaemic, antihyperlipidemic, antioxidative, Musa paradisiaca, Coccinia indic a

Ethiopian Pharmaceutical Journal Vol. 25 (1) 2007: pp. 9-22