In vitro antioxidant activity of new thiophene ring-based compounds

Abstract

Free radicals are implicated in causation of various histo-pathological disturbances like myocardial ischemia injury, cancer, neurodegenerative diseases, hepatic disorders etc. Newer chemical entities (SMRK-1 and SMRK-10) of thiophene class were synthesized and tested for the antioxidant property by super oxide scavenging effect and lipid peroxidation inhibition activity. The results indicated that SMRK-1 and SMRK-10 had shown more than 50% inhibition in the formation of blue formazan in superoxide scavenging activity and inhibition of lipid peroxidation to the extent of 65% by preventing pink chromogens. These observations suggest that the newer compounds (SMRK-1 and SMRK-10) at the tested doses possess an antioxidant effect.

Keywords: thiophene derivatives, synthesis, antioxidant, superoxide scavenging, lipid peroxidation inhibition

Ethiopian Pharmaceutical Journal Vol. 23 2005: 53-57