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Propylthiouracil-Induced Seropositive Vasculitis with Alveolar Hemorrhage: A case report
Abstract
Propylthiouracil (PTU) is a commonly used anti-thyroid medication. As a rare complication, PTU can induce antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV), resulting in nephritis and alveolar hemorrhage. Here we presented a 52 years old Ethiopian woman who developed AAV during her PTU therapy for toxic goiter. Her clinical, laboratory, and chest imaging were all consistent with the diagnosis. She showed marked improvement after discontinuation of the medication and the addition of corticosteroid and cyclophosphamide. Our case, the first in Ethiopia, illustrates the importance of attentiveness, early identification, and management of this
rare side effect of PTU therapy.
