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Aug 4, 2023Keywords:
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Association of microalbuminuria with metabolic indicators of atherosclerosis and inflammation in type 1 diabetic patients
Abstract
Background: Microalbuminuria is usually accompanied by undiagnosed dyslipidemia. We aimed to assess the correlation between microalbuminuria and early atherosclerotic changes in type 1 diabetics by comparing two groups of patients according to their UAER (Urinary Albumin Excretion Rate) status.
Methods: We conducted a retrospective study including 167 patients with confirmed type 1 diabetes segregated into the following groups (patients with normoalbuminuria vs. patients with microalbuminuria).
Results: Our study revealed a definite preponderance of males (52.10%). The mean age was 29.55±11.36 years, whereas the diabetes duration was 12.73±8.14 years. The prevalence of microalbuminuria was 39.5%. Significant correlation was observed between lipid profiles such as TG and LDL (r=0.227; r=0.166, respectively) and lipid ratios TC/HDL, LDL/HDL, and TG/HDL (r=0.322; r=0.351; r=0.386, respectively) with UAER. The findings showed that the last quartile of TC/HDL ratio (cOR=6.89[2.61-18.14]; p<10- ³) and LDL/HDL ratio (cOR=5.48 [2.10-14.30]; p=0.001) were higher in microalbuminuric patients. Similarly, we noticed higher values in the last two quartiles (3rdand 4th) of the TG/HDL ratio with p values of 0.05 and 10- ³, respectively. TG/HDL ratio was a strong indicator for atherosclerotic disease (sensitivity of 82.1%, specificity of 84.2%, and diagnostic accuracy of 0.775). In contrast to females who developed microalbuminuria, lipid ratios and lipid profiles were significantly greater in male patients.
Conclusions: Patients who develop microalbuminuria are characterized by dyslipidemia and a higher risk of atherosclerotic cardiovascular disease. Hence, early detection of microalbuminuria associated with dyslipidemia is crucial for the effective prevention of atherosclerotic cardiovascular diseases.
