Voltammetric determination of paracetamol at glycine modified carbon paste electrode

Abstract

The lower body tolerance of paracetamol (PCT) is 50 ppm and if it surpasses; PCT will led to accumulation of toxic metabolites. A carbon paste electrode modified with glycine (GlyCPE) is used for the detection of PCT at relatively low concentrations. In contrast to the bare carbon paste electrode (CPE), an improved onset potential with a shifting of 85 mV and enhancement of anodic peak current at the modified electrode resulted in a the GlyCPE surface with a material that possesses an electroanalytical activity toward the oxidation of PCT. Differential pulse stripping voltammograms (DPSV) of PCT oxidation on the GlyCPE yielded a well-defined oxidation peak of 0.61 V in a 0.1 M phosphate buffer solution of pH 6.0 with a linear calibration from 5.0 to 1000 mM with R² = 0.995. The DPSV detection limit was projected to be 0.12 mM. In the presence of the interfering ascorbic acid (AA) of 50 and 100 mM, the GlyCPE was able to detect the PCT (100 mM) with a percentage of detection of 100.16 and 97.79, respectively, which did not affect significantly the peak current response of the PCT. Besides, the fabricated GlyCPE accurately measured the amount of PCT in three brand pharmaceutical samples.