Differential pulse stripping voltammetric determination of paracetamol in pharmaceutical tablet samples using murexide modified carbon paste electrode

Abstract

As an acetyl aniline drug, paracetamol (PA) has antipyretic and analgesic functions, which is suitable for the remedy of fever, headache and joint ache. The murexide modified carbon paste electrode was characterized by cyclic voltammetry and electrochemical impedance spectroscopy and compared with bare carbon paste electrode. In this study, murexide-carbon paste electrode (MXCPE) was described for the differential pulse stripping voltammetric determination of paracetamol in pharmaceutical tablet sample. The MXCPE exhibited a better electrocatalytical behavior for the oxidation of PA as evidenced by nearly two folds of current enhancement and a shift of the onset potential by 65 mV in comparison with a bare carbon paste electrode. Differential pulse stripping voltammetry peak currents of PA increased linearly with their concentrations in the ranges of 5-1000 mM with a detection limit of 0.09 mM (S/N = 3). The determination of the analyte in pharmaceutical samples was found in the range 97.6-106.0% of the theoretical values and a recovery result between 94.6 and 96.8% was obtained. For selective determination of PA in the presence of AA was successfully performed.