Platelet activating factor and monocyte chemoattractant protein-1 in children with refractory epilepsy

Abstract

Background: Epilepsy is an important common and diverse group of symptom complexes characterized by recurrent spontaneous seizures. It is estimated that about 5-10% of all cases of epilepsy eventually become refractory. It has been suggested that inflammation plays a role in epilepsy. In refractory epilepsy, an inflammatory response is produced that leads to rapid release of pro-inflammatory cytokines as platelet activating factor (PAF) and monocyte chemoattractant protein-1 (MCP-1). Objective: The aim of the present study was to evaluate the plasma levels of the monocyte chemoattractant protein-1 (MCP-1) and platelet activating factor (PAF) in children with refractory epilepsy to explore their role in the pathogenesis of refractory epilepsy. Methods: The present study was carried out in Tanta University Hospital, Pediatric Department, Neurology unit. Forty (40) children with idiopathic refractory epilepsy (25 males and 15 females) their age ranging between 4-15 years were included in the study. The control group consisted of thirty healthy children, 20 males and 10 females aged 5 years to 13 years. The serum levels of MCP-1 and PAF were measured for children with refractory epilepsy and the control children. Results: Children with refractory epilepsy had significantly higher serum levels of PAF (P < value 0.001) and significantly higher serum level of MCP-1 (P < value 0.001) in comparison to the control children. Also there was a significant correlation between the duration of refractory epilepsy and the serum levels of PAF and MCP-1. Conclusion: Higher serum levels of the proinflammatory cytokines PAF and MCP-1 in children with refractory epilepsy suggest that both, PAF and MCP-1, may play a role in the pathogenesis of refractory epilepsy.

Keywords: Platelet activating factor, Monocyte chemoattractant protein-1, Neuroinflammation, Refractory epilepsy

Egypt J Pediatr Allergy Immunol 2012;10(1):13-18