Could Preoperative Thrombocytosis be a Marker in Different Gynecological Malignancies?

Abstract

Background: Thrombocytosis is a condition in which the platelet (PLT) count exceeds 400,000/μl. It could be considered a bad indicator  for several forms of malignant tumours.

Objective: The aim of this work was to study if thrombocytosis could be a marker in gynecological malignancies.

Patients and methods: This cross-sectional observational study was conducted on 196 patients who had gynecological malignancies at  Gynecology and Obstetrics Department, Mansoura University Hospital through the period from March 2022 to November 2023

Results:  The correlation analysis revealed that there was a significant relation between type of cancer and thrombocytosis. In endometrial  carcinoma there was 27 patients (40.9%) had stage 1 a and 8 of them (12.1%) had thrombocytosis. 29 patients (43.9%) had stage 1 b and 2  patients (6.1%) had stage 3 and all of them had thrombocytosis. 8 patients (12.1%) had stage 4. In sarcoma there was 5 patients (45.1%)  had stage 1 a and 6 patients (54.9%) had stage 4. In ovarian cancer (OC) there was 3 patients (5.7%) had stage 1 a, 20 patients  (37.7%) had stage 1 b and 4 of them (7.5%). 16 patients (30.2%) had stage 2 b and 5 of them had thrombocytosis. 14 patients (26.4%) had  stage 3 and 5 of them had thrombocytosis.

Conclusion: Thrombocytosis could be a marker in gynecological malignancies. there was  significant relation between type of cancer and thrombocytosis. In which thrombocytosis was found in endometrial carcinoma, ovarian  cancer and cancer cervix respectively