Nanofat for Infraorbital Rejuvenation: A Clinical and Dermoscopic Evaluation

Abstract

Background: Infra-orbital dark circles (IDC) can affect people of different ages, all races and both genders. Nanofat injection is a quite  popular modality in tissue reconstruction.

Objective: To assess the clinical effectiveness, safety and potential side effects of nanofat  injection for infraorbital rejuvenation. Patients and Methods: The study included 30 subjects with IDC and/or tear trough deformity (TTD). They were injected with nanofat and followed up for 3 months. The clinical assessment included the grade of infraorbital hyperpigmentation, tear trough rating scale (TTRS), global evaluation of the improvement degree, and the improvement degree of skin  texture and homogeneity. Dermoscopy of infra-orbital region were performed for IDC classification.

Results: IDC were significantly  improved in 60% of the subjects. Regarding satisfaction, 15 subjects (50%) were highly satisfied, 9 subjects (30%) were satisfied and 6  subjects (20%) showed slight satisfaction.

Conclusion: Nanofat injection is beneficial for skin rejuvenation and per the post-operative skin  texture changes. No contour  irregularities or lumps were observed at three months of follow-up. Nanofat injection is safe and easy,  with low tissue morbidity, making it a novel treatment modality for facial rejuvenation and restoration.