Study of Interleukin 33 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis

Abstract

Background: Allergic rhinitis (AR) is a chronic illness, which most people are afflicted by.

Objective: To evaluate the expression of interleukin-33 in patients presenting with allergic rhinitis and nasal polyposis.

Patients and Methods: This study was carried out on 50 patients aged from 15 to 40 years old, both sexes, and 25 healthy volunteers  matched in age and sex. Patients were allocated into two groups: Case group n= 50 and control group n= 25, then the case group was  further subdivided into equal two groups: nasal polyposis group n= 25, and AR group n= 25. All patients were subjected to laboratory  investigations, DNA extraction, measurement of DNA concentration, and single nucleotide polymorphism detection.

Results: The most  predominant genotype in sinusoidal nasal polyps was CT (60%) in both tissue and serum.

Conclusions: Il 33 genotype (rs11792633)  wasn’t associated with allergic rhinitis and nasal polyps.