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Clinical Significance of HLA DPB1 (SNPrs3116996 & SNPRs2071025) Gene Polymorphism in Liver Cirrhosis Development among Egyptian Patients with Chronic HCV Infection


Elsayed Ibrahim Abdelrhman Ali
Samia Ali Abdo Gamie
Enas Mahmoud Foda
Samah Ahmed Bastawy
Heba Ahmed Osman
Abeer Mohamed Mahmoud Sabry

Abstract

Background: Chronic liver disease, which can lead to cirrhosis and hepatocellular carcinoma (HCC), is mostly caused by hepatitis C. 


Objective: We aimed to clarify the association between HLADPB1 expression and chronic HCV infection in Egyptian patients.


Patients and methods: 85 adult participants were enrolled in this study. They were divided into three groups: Group 1 included 20  cirrhotic patients with HCV, group 2 included 20 chronic HCV patients and group 3 included 45 healthy controls. HLADPB1SNPrs3116996  and HLADPB1 SNPRs2071025 polymorphism were assessed.


Results: There was significant higher frequency of HLADPB1SNPrs3116996  genotype TA in cirrhotic HCV patients in comparison with chronic HCV patients and healthy controls (40%, 15% and 4.4 % respectively;  p=0.002). Also, cirrhotic HCV group had significantly higher frequency of A allele when compared to chronic HCV group and healthy controls (20.0%, 7.5% and 2.2% respectively; p0.001). HLADPB1 (SNPRs2071025) genotypes AG in patients with cirrhotic HCV, chronic  HCV patients and healthy control were 45%, 25% and 8.9% respectively with significant Pvalue (0.001). In addition, there was significantly  higher allele G frequency among the cirrhotic HCV patients (22.5%) followed by chronic HCV patients (17.5%) compared to controls (4.4%)  with significant p-value (0.002).


Conclusion: HLADPB1SNPrs3116996 genotype TA and HLADPB1 SNPRs2071025 genotype AG carry risk of  liver cirrhosis development in patients with chronic HCV infection and deterioration of clinical and biochemical parameters.  


Journal Identifiers


eISSN: 2090-7125
print ISSN: 1687-2002