Role of Histological Investigation in The Protective Evaluation of Ginger

Abstract

Background: Monosodium glutamate (MSG) usage has been increased in the industry year after year reflecting its crescent use in the food industry. MSG toxicity is specific to the tissue in the body. Herbal drugs provide a managing role for several hepatic disorders so it is critical to find an effective and preventive agent to manage various hepatic insults.

Objective: This experimental study aimed to examine the possible protective effect of ginger extract against injury induced by MSG as a therapeutic agent in pharmaceutical therapies.

Materials and methods: Four groups of rats were divided and obtained treatment periods, after that they conducted serial histological and histochemical changes in control, MSG- and ginger-treated rats, focusing particularly on liver pathology.

Results: MSG exhibited histological and histochemical changes in the liver. Such alterations induced hepatopathology, involving a return to a somewhat normal condition-ginger treatment.

Conclusions: Ginger as herbal supplementations speed up the healing progression of hepatotoxicity. This study reports the effect of ginger exerts anti-toxicity and anti-fibrotic potentials.