Serum Osteopontin and its Relation to Colorectal Carcinoma in Egyptian Patient

Abstract

Background: Colorectal cancer (CRC) incidence has increased worldwide recently, and the death rate from it has increased to reach 10% of cancer-related deaths. Many risk factors are expected to play a role in this high incidence such as the higher age, change in dietary habits, cigarette smoking, low physical exercise, and the increased prevalence of obesity of the populations worldwide. Objectives: To evaluate the role of serum level of osteopontin in prediction of colorectal carcinoma in correlation with tissue histopathology, which is the gold standard test.

Patients and Methods: This study was conducted on 80 subjects referred for colonoscopy at the Endoscopic Unit of Ain Shams University Hospitals. Patients were divided into 2 groups: Group A included 40 patients diagnosed as colorectal carcinoma as a patient group and group B that included 40 individuals with age- and sex-matched who had normal colonoscopy and was used as control group.

Results: The level of osteopontin was statistically significant higher in CRC patients than in subjects with normal colonoscopy. Also, the ROC curve for osteopontin in prediction of CRC showed the best cut of value of > 12 ng/ml with area under the curve (AUC) = 0.889, sensitivity = 85% and specificity = 77.5%.

Conclusion: Serum Osteopontin (OPN) level was detected in our study to be high in patients with CRC in comparison to patients with normal colonoscopy. Therefore, it can be used as a biomarker in the diagnosis of CRC. Also, serum osteopontin level is significantly higher in cancer patients with metastasis according to TNM staging, thus it can be used in prognosis.