Relation between Interleukin 8 and Bronchial Asthma in Children: Review Article

Abstract

Background: Asthma is a frequent respiratory condition to treat. A persistent airway inflammation characterizes this frequent form of pulmonary disease. Immune responses are triggered by cytokines and chemokines produced by airway epithelial cells. Human bronchial epithelial cells secrete IL-8 in response to the presence of interleukin-4 (IL-4) and interleukin-13, both of which are increased in asthmatics. There are two receptors for IL-8, the IL-8 receptor alpha (also known as CXCR1) and beta (also known as the IL-8 RB, CXCR2). IL8 is a potent chemotactic cytokine that activates
inflammatory cells by recruiting mast cells, mononuclear phagocytes T lymphocytes, and neutrophils to the site of inflammation.

Objective: To determine the relationship between IL8 and bronchial asthma in children.

Conclusion: The assessment of IL8 levels in pediatric asthmatic patients is a useful biomarker reflecting the status of asthma and also to glucocorticoids and treatment responses.