Head and neck cancer association to CIAP-2 expression due to human papillomavirus-16 (HPV-16) infection

Abstract

It was relevant to assess the impact of a HPV-16 (human papillomavirus-16) which is a high-risk genotype on head and neck cancers and its relation to CIAP-2 expression (Cellular Inhibitor of apoptosis-2). Tissue samples were taken from patients diagnosed as head and neck cancer. All samples were subjected to qualitative polymerase chain reaction (PCR) analysis for HPV, qualitative and semi-quantitative reverse transcription polymerase chain reaction (RT-PCR) of CIAP-2. There was a significant association between HPV-16 & CIAP2 positivity and head and neck tumors. CIAP-2 expression in malignant tissues was highly associated with HPV-16 infection at sensitivity 73.9 % and absolute specificity.

key words: Papillomavirus, HPV-16, Rt-PCR, CIAP-2.