Impact Of Administration Mulberry Juice On Blood Glucose, Lipid Profile And Oxidative Stress In Normal And Diabetic Rats

Abstract

The aim of the present study was designed to study the effects of black and white mulberry juice on blood glucose, lipid profile and oxidative stress in normal and diabetic rats. Sprague Dawley male rats weighing (125 ± 12.2 g) were divided into eight groups (each of 12 rats). Four healthy control group include normal control, normal black mulberry, normal white mulberry and normal mixture of black and white mulberry, while the remaining four groups were induced diabetic rats by injected intraperitonelly with 100 mg/kg body weight of alloxan (diabetic control, diabetic received black mulberry, diabetic received white mulberry and diabetic received mixture of black and white mulberry). Results show significant elevation in serum glucose (280%) in diabetic control group compared to normal control group, while administration of mulberry juice decreased serum glucose concentration by 45%, 20% and 37% in diabetic black mulberry, diabetic white mulberry and diabetic mixture mulberry, respectively as compared to diabetic control group. However, the mulberry juice significantly increase the concentration of reduced glutathione (GSH)
and erythrocyte SOD activity. Also mulberry juice significantly decrease oxidative stress which manifested by decrease the level of MDA and NO. The alloxan produced significant increase in ALT and AST, urea and creatinine in diabetic control group as compared to normal control group. While, the administration of mulberry juice decreased the levels of ALT, AST, urea and creatinine in diabetic group compared to diabetic control group. However mulberry juice is the highly effective on lipid profile and atherogenic index which were manifested by decrease (TAG), TC, LDL, and atherogenic index and increase (HDL-C) as compared to diabetic control group (P < 0.05). It was concluded that the mulberry juice has considerable hypoglycemic and hypocholestronic effect and strengthening antioxidant, it able to reduce diabetic complications especially black mulberry, to rich in anthocyanin.

Keywords:Mulberry juice, Alloxan, blood glucose, hypoglycemic,
lipid peroxide.