The Lipoprotein Lipase HindIII Polymorphism And The Susceptibility To Hypertension

Abstract

Lipoprotein lipase (LPL) enzyme plays a central role in lipid
metabolism. The primary function of LPL enzyme is the hydrolysis of
the core triglycerides of circulating chylomicron and very low density
lipoprotein (VLDL). It releases monoglycerides and free fatty acids,
which are taken up by skeletal muscle or adipose tissue. The present
work aimed to study the association of the common variant of LPL
HindIII (H+) and hypertension. HindIII (+) variant allele of LPL were
determined by polymerase chain reaction restriction fragment length
polymorphism (PCR-RFLP) assay in 150 hypertensive patients and
150 normotensive as a control group. Serum lipoproteins were also
observed in both groups. Allele frequencies were H+ = 0.733 and H- =
0.267 for LPL HindIII in the hypertension group compared to H+ =
0.683 and H- = 0.317 in the control group. Individuals with
homozygous (H+/+) genotype were at higher risk of developing
hypertension compared to the (H-/-) genotype (Odds Ratio OR= 2.13,
95% Confidence Interval CI= 0.937-4.8). Serum TG level were also
higher in the individuals with (H+/+) genotype compared to the (H-/-)
genotype, while HDL showed negative correlation with the presence
of (H+/+) genotype. It can be concluded that the LPL HindIII (H+)
variant of LPL may influence the blood lipid metabolism and increase
risk for hypertension.

Key words: hypertension; HDL; LPL HindIII polymorphism; triglycerides.