Levels Of Serum Intercellular And Vascular Adhesion Molecules In Insulin Dependent Diabetic Nephropathy Patients

Abstract

The study evaluated the possible significant role of soluble
intercellular and vascular adhesion molecule-1 (sICAM-1 and
sVCAM-1), sE-selectin and interluekin-1β in development
nephropathy in patients with insulin dependent diabetes mellitus
(IDDM). This study included 60 patients with type 1 diabetes mellitus
(IDDM), together with 20 healthy control subjects. Patients were
divided into 3 groups according to the onset of disease. All studied
groups were subjected to clinical and laboratory evaluation of serum
soluble sICAM-1, sVCAM-1, sE-selectin, IL-1β in association with
microalbumin, and CRP. A highly significant elevation of soluble
adhesion molecules (sICAM-1, sVCAM-1 and sE-selectin) and
microalbuminuria were observed in patients with IDDM, while there
was no significance difference in IL1-β in the same patients. Our
findings may have clinical implications, since they may indicate that,
these adhesion molecules are known as very strong marker for renal
complications and the circulating forms of these adhesion molecules
have been associated with clinical vascular events and all-cause
mortality in the renal population.

Keywords: Adhesion molecules, IDDM, diabetic nephropathy