Evaluation of anti inflammatory properties and possible mechanism of action of Egyptian quince (Cydonia oblonga) leaf

Abstract

The present study aimed to investigate the antiinflammatory effect of Cydonia oblonga (COL) evaluated by the following models: arachidonic acid-induced ear edema and carrageenan-induced paw edema in rats. The levels of glutathione (GSH), lipid peroxidation (LPO), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nitric oxide (NO) in the hind paws of the carrageenan-treated rats were estimated. Moreover, the activities of catalase (CAT) and glutathione-S-transferase (GST) were investigated. The results showed that COL significantly reduced ear edema and paw edema in the rats. Furthermore, treatment with COL decreased the levels of LPO, NO, IL-6 and TNF-α, whereas increased the level of GSH. The increased activities of CAT and GST enzymes were ameliorated by COL administration. In conclusion, Cydonia oblonga possesses potent antiinflammatory activity through inhibition of NO, LPO, IL-6 and TNF-α levels leading to alleviate edema.

Keywords: antiinflammatory, CAT, GST, IL-6, TNF-α, GSH, quince