Formulation and Evaluation of Tenoxicam Niosomes

Abstract

This study aimed at investigating the influence of varying proportions of the surfactant span 60, cholesterol and dicetylphosphate on the morphology, particle size distribution, entrapment efficiency and in vitro drug release of encapsulated tenoxicam niosomes. In vitro stability studies of the niosomes were then performed using blood from albino rats. Drug release from the niosomes showed biphasic sustained release pattern of tenoxicam for a period of 24 h. The results obtained show that niosomes of tenoxicam can be prepared as carriers for transdermal therapy..

Keywords: Niosomes, Tenoxicam, Cholesterol, Span 60, Dicetyl phosphate

The East and Central African Journal of Pharmaceutical Sciences Vol. 8 (3) 2005: pp 62-66