Peak Purity Assessments in Chrmatography: A Case Study of Chlorpromazine Hydrochloride

Abstract

This work examines the applicability of different peak purity and/or homogeneity deconvolution algorithms for the evaluation of chromatographic purity and/or homogeneity in chlorpromazine hydrochloride, in the order of the algorithm\'s increasing complexity. The methods are examined for usefulness with a view to possible routine application in a busy quality assurance laboratory include chromatographic peak assessment, spectral normalization, absorbance ratios and chromatographic derivatives.

Key Words: Chlorpromazine hydrochloride, chlorpromazine impurities and chromatographic peak purity.


East and Central African Journal of Pharmaceutical Sciences Vol.5(3) 2002: 55-59