Estrogenic and Anti-Inflammatory Activities of a Steroidal Indoxyl

Abstract

The estrogenic and anti-inflammatory activities of 3-methoxy-16, 17-seco-16-norestra-1,3,5-trien-15-(2'-indoxyliden)-17-oic acid is reported. After intraperitoneal administration, the dose of this compound required to reduce swelling of the rat paw by 50% (ED₅₀) was 14.1 mg/kg using the carrageenan-induced rat paw oedema anti-inflammatory assay method. Indomethacin had an ED₅₀ of 3.2 mg/kg in this assay while dexamethasone had an ED₅₀ of 1.7 mg/kg. The estrogenic activity of the compound after intramuscular administration in rats was 0.72 relative to diethylstilbestrol, when the two compounds were assayed at three dose levels of 1.0, 0.3 and 0.1 mg/kg.

Key Words: Steroidal indoxyl, synthesis, estrogenic, anti-inflammatory

East and Central African Journal of Pharmaceutical Sciences Vol.5(3) 2002: 44-48