Vaccination of BALB/c mice with Leishmania donovani derived lipophosphoglycan does not conver cross-protection to L. major infections

Abstract

Objective: To determine whether Leishmania donovani-derived lipophosphoglycan (LPG) can confer cross-protection to L. major in susceptible BALB/c mouse model. BALB/mice were immunized with a total dose of 30µg of LPG plus 150µl of mycobacterium bovis Bacille Calmette guerin (BCG) and later challenged with virulent L. Major parasites. The results demonstrated an activation of both the humoral as well as cell-mediated response to LPG mixed with BCG which correlated with resistance against the disease. However, immunized mice were not protected compared to their PBS controls.


(East African Medical Journal: 2003 80(5): 260-263)