The association between hyperuricemia and blood pressure among haemodialysis patients, single center study

Abstract

Background: Both hypertension and hyperuricemia are known clinical presentations associated with chronic kidney disease (CKD); however, the link between them has not been studied among haemodialysis patients.

Objective: The aim of this study is to evaluate the association between hyperuricemia and hypertension in hemodialysis patients.

Design: This is a cross sectional analytic study

Setting: Academy Teaching Hospital,  haemodialysis center in Khartoum/Sudan.

Materials & methods: All patients attending the hemodialysis center during the study period participated in  the study. Clinical information required were; systolic blood pressure (SBP), diastolic blood pressure (DBP) and weight. laboratory data included were;  serum uric acid, creatinine and hemoglobin. Hyperuricemia defined as serum uric acid level (SUA) level of ≥6.0 mg/dl.

Results: The study showed that  67.8% of the study population were males, mean age 58.57 ± 12.25 years. Of these 41% of patients had a SUA level of ≥ 6 mg/dl, the mean level of SUA  was 5.59 ± 1.45 mg/dl. A higher level of (SUA) was significantly associated with higher SBP (P < 0.001) and higher DBP (P < 0.001). Younger patients were  significantly having higher level of SUA (P = 0.027). and a high SUA level significantly predicts SBP (p = 0.002) and DBP (p = 0.001) among the hemodialysis patients on univariate and multivariate analysis respectively.

Conclusion: The study results showed that; hyperuricemia is common among the participants, high (SUA) is a predictor of high SBP and high DBP among hemodialysis patients.