A rare case of malignant Phylloides tumour of the breast in Neurofibromatosis Type 1: Not just a sporadic occurrence?

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant multisystem disorder that predisposes to rare malignancies. Performing molecular studies in Neurofibromatosis type 1 (NF1) patients may prove useful in determining susceptibility to these malignancies. We describe a rare case of a twenty-two (22) year old woman with NF1 presenting with malignant phylloides of the breast. Due to paucity of guidelines, we describe challenges encountered during management.