Infratentorial glioblastoma multiforme: case report and review of literature

Abstract

Glioblastoma multiforme (GBM) is the commonest and most malignant form of the gliomas. The tumour accounts for 45% of malignant primary brain and Central Nervous System (CNS) tumours, 54% of all gliomas and 16% of all primary brain and CNS tumours. We present a seven year old female child who presented with a one month history of right sided headache, progressive right sided hemiparesis, and tremor with no history of infection or trauma. Investigations which included computerized tomography scanning, Magnetic Resonance Imaging, Magnetic Resonance Spectroscopy and Tractography. These revealed a homogenously hypo-dense mildly ring enhancing lesion in the right brain stem, with mass effect displacing the 4th ventricle to the left, among others. Retro sigmoid craniotomy and concurrent ventricular drain placement was performed with post-operative period being uneventful. Histopathology confirmed malignant Glioblastoma multiforme and the patient was commenced on Temozolimide and radiotherapy with satisfactory results.