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Management outcome of ocular surface conjunctival neoplasia
Abstract
Background: Ocular surface squamous neoplasia (OSSN)are aspectrum of lesions that arise from the squamous epithelium of the conjunctiva and cornea. They form the most frequent indication for orbital exenteration in Korle-bu Teaching Hospital, Accra. Poor management of early lesions leads to high rates of tumour recurrence and extension to adjacent structures.
Objective: To determine the management outcome of combined surgical excision followed by topical 1% 5-flourouracil (5-FU) in patients presenting with early OSSN limited to the ocular surface.
Design: retrospective clinical study
Setting: Korle bu Teaching Hospital, Accra, Ghana
Subjects: The records of all patients who presented with OSSN at the eye clinic of Korle-bu Teaching Hospital, Accra between May2013 and June 2014 were reviewed retrospectively. Data on age, sex, HIV status, histology results and treatment outcome were recorded and analysed.
Results: The mean age of patients was 43.2 ±12.17years (range-18 to 59years).At 6 weeks of follow up, all 18 patients seen were clinically free of tumour. At six months of follow seven (33.9%) patients had defaulted and there was one (5.6%) recurrence. The main complication was corneal epithelial keratitis which resolved following cessation of topical 5-FU
Conclusion: Ocular surface squamous neoplasiais effectively treated with excision and application of 1% 5 Fluorouracil with minimal side effects. The drug is readily available and affordable. However, a longer duration of follow up is required to adequately evaluate long term recurrence rates.
Objective: To determine the management outcome of combined surgical excision followed by topical 1% 5-flourouracil (5-FU) in patients presenting with early OSSN limited to the ocular surface.
Design: retrospective clinical study
Setting: Korle bu Teaching Hospital, Accra, Ghana
Subjects: The records of all patients who presented with OSSN at the eye clinic of Korle-bu Teaching Hospital, Accra between May2013 and June 2014 were reviewed retrospectively. Data on age, sex, HIV status, histology results and treatment outcome were recorded and analysed.
Results: The mean age of patients was 43.2 ±12.17years (range-18 to 59years).At 6 weeks of follow up, all 18 patients seen were clinically free of tumour. At six months of follow seven (33.9%) patients had defaulted and there was one (5.6%) recurrence. The main complication was corneal epithelial keratitis which resolved following cessation of topical 5-FU
Conclusion: Ocular surface squamous neoplasiais effectively treated with excision and application of 1% 5 Fluorouracil with minimal side effects. The drug is readily available and affordable. However, a longer duration of follow up is required to adequately evaluate long term recurrence rates.
