Antibiotic Resistance Conferred by Class 1 Integron in Vibrio Cholerae Strains: A Meta-analysis

Abstract

Background: Class 1 integron is the most ubiquitous platform among antibiotic resistance bacterial populations, including Vibrio cholerae strains. This meta-analysis aimed to determine the antibiotic resistance conferred by class 1 integron conserved segments (CS); 3’-qacEΔ1 and sul1, and 5’-int1 in V. cholerae strains.
Methods: An intensive literature search of electronic databases for relevant studies from their starting dates up to April 2019 was conducted by two independent investigators. The electronic databases included; PubMed, Ovid Medline and Google Scholar databases. Only studies that determined antibiotic resistance conferred by class 1 integron in V. cholerae strains isolated from clinical and/or environmental samples using Polymerase Chain Reaction (PCR) assay were included in this study.
Results: The random-effects model was selected and performed for all the studies included in this meta-analysis. Fourteen studies consisting of both qacEΔ1 and sul1, and int1 in the class 1 integron of V. cholerae strains were included. The proportions of class 1 integron 3’-CS and 5’-CS were 70.4 % (95%CI: 37.5–94.4) and 52 % (95% CI: 6.3–95.7) respectively.
Conclusions: The proportions of class 1 integron in V. cholerae strains significantly contributed to the antibiotic resistances, which are comparable to other gram-negative bacteria clinical isolates. Moreover, the 3’-CS qacEΔ1 and sul1 are highly involved in the antibiotic resistance in comparison to 5’-CS int1. Generally, the study findings provide a general view on antibiotic resistance conferred by class 1 integron in Vibrio cholerae strains.