Synthesis and Bioactive Appraisal of Mixed Complexes Mn (II) and Salicylhydroxamic Acid using Oxalic Acid

Abstract

Several synthesized metal ions of transition metals from mixed ligand form complexes due to coordination bond which can be soluble in  polar or non- polar solvents depending on conditions. This study was aimed to synthesis ligands of salicylhyroxamic acid (SHA) and oxalic  acid that formed Mn (II) ion complexes. The solubility test on yielded complexes showed positive effects on methanol, ethanol while Di- methyl sulfoxide (DMSO) became inert under distilled water and chloroform. Melting point test revealed that mixed complexes and SHA  are within the temperature range of 180^oC to 300^oC respectively. The functional group present in complexes investigated using FTIR  showed C=O, C=C and C-O stretching’s with O-H and M-O coordination’s. The complexes was characterized using UVvisible where peaks  of the ligands and the mixed complexes in DMSO showed the maximum absorbance at 300 nm, whose concentrations have uniform  horizontal values that indicated the n→∏* transition of the ligand SHA. The antimicrobial activity tested on the ligand SHA (C₇H₇NO₃), complexes and reference drug investigated against four bacterial species; staphylococcus aureus, Escherichia coli, Klebsilla pneumonia  and Salmonella typhi and two fungi species candida albicans and Aspergillus niger that involved agar disc diffusion methods showed  diameter of inhibitions zone of individual sample analyte are dignified. A momentous activity of Mn (II) complexes observed on investigated micro-organisms of the mixed complexes syntheses showed effective anti-microbial agent in this research.