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Antibiotics susceptibility profile of extended beta-lactamase-producing Escherichia coli in urine samples from pregnant women attending Ajikobi Hospital, Ilorin, Kwara state
Abstract
One of the most frequently acquired infections is urinary tract infection and Escherichia coli is a major causative pathogen. This study aims to determine the prevalence and antibiotic susceptibility of E. coli and extended-spectrum beta-lactamases (ESBLs) producing E. coli in urine samples of antenatal pregnant women attending Ajikobi Hospital in Ilorin, Nigeria. The study was conducted on urine samples from 117 consented pregnant women attending the antenatal clinic between January and October 2022. They were screened for Escherichia coli and Extended-spectrum β-lactamase producing E. coli using standard microbiological procedures such as growth on Eosin methylene blue, Gram staining, and biochemical tests. Antibiotic susceptibility testing was done by the modified Kirby-Bauer protocol while ESBL production was determined by the Double Disk Synergy Test (DDST). A total of 117 samples were screened, 26 (22.2%) showed significant bacteriuria, and 18 (69%) E coli was isolated. The age distribution shows that 15- 20 years has a prevalence rate of 23.1%, 21- 25 years (24.1%), 26- 30 years (25%), 31-35 (21.6%), and women above 35 years (27.3%). Antibiotic sensitivity profile shows that 16.7% were resistant to gentamicin, 66.7% to cefuroxime, 27.8% to meropenem, 11.1 % to ceftriaxone, ceftazidime (33.3%), 16.7% to amoxicillin/clavulanic, 22.2 % to ciprofloxacin and 100% susceptibility to both ofloxacin and nitrofurantoin. The study shows the prevalence of ESBLproducing E. coli and the high susceptibility of nitrofurantoin and ofloxacin.