Occurrence of inducible clindamycin resistance among clinical isolates of Staphylococcus Aureus in some selected hospitals of Kano Metropolis, Nigeria

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is a major public health concern worldwide, responsible for infections in both healthcare settings and the general population. The emergence of multidrug-resistant MRSA strains, including those resistant to macrolides and lincosamides, poses a serious threat to effective treatment due to this bacterial infection. This study aimed to determine the occurrence and resistance pattern of Staphylococcus aureus resistant to methicillin and inducible clindamycin resistance in some clinical isolates from selected hospitals in Kano metropolis, Kano State, Nigeria. Clinical isolates of MRSA were collected from patients diagnosed with various clinical infections in selected hospitals in Kano Metropolis. Antimicrobial susceptibility testing was performed using standard methods, and the presence of inducible clindamycin resistance genes (erm genes) was detected using D-test detection technique. One hundred and fifty (150) clinical isolates of S. aureus were collected for the purpose of this study. The prevalence rate of 39.3% MRSA and 12.0% inducible clindamycin resistance strain among these isolates was obtained. Cotrimoxazole was found to be the most resistant antibiotic against the isolated staphylococcus species in the study. The findings of this study highlight the emergence of MRSA and inducible clindamycin-resistant S. aureus in the study area. Continuous surveillance and monitoring of antimicrobial resistance patterns are essential for effective management of MRSA infections in this region.