Anti-Inflammatory Effect of Ethanolic Leaves Extract of Sansevieria trifasciata and Sansevieria liberica in Swiss Mice, (Mus musculus)

Abstract

The aim of this study was to examine the anti-inflammatory properties of Sansevieria trifasciata, also known as mother-in-law tongue,  and Sansevieria liberica ethanolic leaf extract on mice, (Mus musculus). In a scientific setting, plant powder was extracted using 70%  ethanol over a 72-hour period. Using the test animals, the extracts’ median lethal dose (LD₅₀) was established. The soluble portion of the  extracts was given at working doses of 10, 20, and 30% of the LD₅₀ to the corresponding experimental animal groups (i.e low, middle,  and high dosages accordingly). Findings from Sansevieria trifasciata and S. liberica’s phytochemical screening indicated the existence of  secondary metabolites like terpenes, alkaloids, cardiac glycosides, and tannins. When given intraperitoneally, the LD50 of S. trifasciata  and S. liberica were 387.30 and 353.55 mg/kg, respectively. The plant extracts’ soluble fraction was given intraperitoneally (i.p.) by injection as well as orally. The phlogistic egg-albumin-induced inflammation significantly decreased (p<0.05) according to the results.  However, the development of a strong anti-inflammatory drug with low toxicity and an improved therapeutic index may come from the  isolation of these bioactive components.