Synthesis of AGNPS from the seed oil of Terminalia mantaly and its antimicrobial activities against selected bacteria

Abstract

Antibiotic resistance is a global public health problem that requires innovative alternatives to reduce the loss of life. This study investigated the antibacterial activity of T. mantaly seed oil and synthesized silver nanoparticles (AgNPs) on antibiotic resistant bacterial strains. The seed oil was extracted by the Soxhlet method using n-hexane and petroleum ether and characterised by GC-MS and FTIR analysis. The AgNPs were investigated using a UV-vis spectrophotometer and the antibacterial potential of the oils and AgNPs was evaluated using the agar well diffusion method. The eighteen (18) compounds identified were phenolic esters with 9, 12-octadecadienoic acid (Z, Z), eicosenoic acid and 9-octadecanoic acid being the most prominent in the oils. 3-Hexen-1-ol, diethyl phthalate and 1, 2-benzene dicarboxylic acid were found for the first time in T. mantaly seed oil. AgNPs showed 26.83±3.01 mm activity higher than 19.83±1.89 mm of seed oil with no resistance shown by the test bacteria. While K. pneumoniae and S. aureus showed selective resistance to the oil. The study revealed the potency of AgNPs synthesized from T. mantaly seed oil against antibiotic-resistant bacterial strains due to the presence of novel compounds.