Synthesis, characterization and antimicrobial studies of Schiff base derived from 2-amino phenol and o-anisaldehyde and its Co (II), Cu (II) and Zn (II) complexes

Abstract

Schiff base was synthesized by refluxing 2-aminophenol and o-anisaldehyde, In similar manner, its corresponding Co(II), Cu(II) and Zn(II) complexes were also synthesized and characterized by Solubility Test, Decomposition Temperature, Molar Conductivity Measurement, Infrared Spectroscopy and UV-Visible Analysis. The melting point of the Schiff base was 110 °C and Decomposition Temperature of the complexes were found to be in the range 124 – 136 °C. The IR spectral analysis of the Schiff base showed a band at 1600cm^-1, which was assigned to υ(C= N). The band observed in complexes were in the range 1585-1609 cm^-1. The shift in absorption band indicated coordination of the Schiff base to the metal ion through azomethine group. Magnetic susceptibility revealed that Co (II) and Cu (II) complexes are paramagnetic whereas Zn complex is diamagnetic. The molar conductance values of the complexes were in the range 6.28-22.37 Ω^-1cm²mol^-1 which are low indicating that the complexes are non-electrolytes. Job’s method revealed 1:2 metal to ligand ratio. The ligand and the complexes were tested for antibacterial and antifungal activities against some pathogenic bacteria which are Salmonella typhi, Staphylococcus aureus and Escheria coli and some fungi species which are Mucor spp and Aspergillus fumigatus by disc diffusion method. The results show that the complexes have higher activity than the free Schiff base. The activity increases with increase in concentrations. All the complexes are more potent antibacterial than antifungal.