Assessment of Capsule Related Antibiotic Resistance of Pseudomonas aeruginosa Isolated from Patients Attending some Hospitals in Kano State, Nigeria

Abstract

Resistance to antimicrobial substances by pathogenic microorganisms is on the rise since the beginning of modern medicine. Mechanisms; enzymatic degradation, loss of target and antimicrobial interception are employed by bacteria in resisting antimicrobials. Bacterial capsule is a gelatinous outer layer surrounding a bacterial cell composed primarily of polysaccharide. This study assessed the role that the capsule of Pseudomonas aeruginosa played in carbapenem resistance. P. aeruginosa was isolated from 49 (16%) samples out of 300 samples screened. India ink staining technique was used to detect the capsule. Capsule was detected in 42 (86%) of the isolates whereas 7 (14%) of the isolates were non-capsulated. All the capsulated strains were resistant to the antibiotics (Meropenem, Doripenem and Imipenem) whereas the non-capsulated strains were susceptible to the antibiotics. The results of this study however suggest the involvement of capsule in the resistance of the antibiotics employed.