Phytochemical analysis and antibacterial activity of stem bark extracts of Detarium microcarpum against bacteria causing gastrointestinal tract infections in humans

Abstract

Detarium microcarpum is used by different ethnic groups for treatment of various diseases in Nigeria and several parts of West African. The      phytochemical constituents of the stembark extract of D.microcarpum were analyzed using qualitative methods. The antibacterial activity of the stembark extracts against Escherichia coli and Staphylococcus aureus were tested using the agar well diffusion method. The phytochemical investigation revealed that presence of tannins, saponin, steroids, flavonoids, glycosides, phenols and terpenoids. The plant extracts exhibited anti bacterial potential against the tested organisms at different concentrations 100 mg/mL , 50mg/mL 25 mg/mL and 12.5 mg/mL )), with S. aureus having the highest zone of inhibition of 21 mm at 100 mg/mL with ethanolic extract. Therefore, this study suggests that D. microcarpum stembark has phytochemical constituents. The antibacterial activity exhibited by the extracts could be as a result of the phytochemicals presents.