Estimation of the Levels of Meperfluthrin Pesticides in the Body Organelles of Albino Rats through Inhaling Smoke Produced by Mosquito Coils

Abstract

The domestic use of mosquito coils as pesticides has been increasing over the years to repel and kill mosquitoes as well as other  household insects especially in the rural areas. Unfortunately, this could lead to excessive accumulation of pesticides in the body organs  due to continuous inhaling of the chemical compounds over a long period of time. And this could result in health issues that include  various kinds of organelle cancers, congenital disabilities etc. For this reason, there is a need to determine the levels of Meperfluthrin  pesticides from mosquito coil smoke. Stock and standard solutions of the analyte were prepared and used for the calibration of the  instrument. Later on, the technique of quick, easy, cheap, effective, rugged and safe (QuEChERS) coupled with dispersive solid phase  extraction (dSPE) was used for sample preparation. Then, the calibrated UV-visible spectrophotometry instrument was used for the  determination of the pesticide residues in the organelle samples of albino rats; blood (SRBL), lungs (SRLU), kidney (SRKI) and liver (SRLI)  after a periodical inhalation of smoke produced by mosquito coils. Similarly analysis was carried out on the organelle samples of the  unexposed (blank) albino rats. Eventually, the results (Average ± Standard deviation) obtained (per 28 days) showed that the analyzed  samples were accumulated with the targeted analyte; SRBL (199 ± 0.03 mg/kg), SRLU (321 ± 0.01 mg/kg), SRKI (129 ± 0.05 mg/kg) and  SRLI (564 ± 0.07 mg/kg) after deducting the concentration from the blank animal organs, respectively. Therefore, these justify the  continuous accumulation of the targeted pesticides over a period of time, which can result in health issues since the average determined concentration of pesticides residue (11 mg/kg per day) was above the maximum daily residue limits (MRLs) of 5 mg/kg documented by  Food and Agriculture Organization of the United Nations, and World Health Organization.