Synthesis, Spectroscopic Studies and Antifungal Activity of 7 -amino-4-methyl-quinolin-2(1H)-one

Abstract

The synthesis of 7-amino-4-methyl-quinolin-2(1H)-one has been successfully carried out, and its structural characterization was perfumed using Fourier Transformed Infrared (FT-IR) and Nuclear magnetic resonance (1H and 13C-NMR) spectroscopic techniques. The compound obtained was off white in colour with percentage yield of 47 and Melting point of 269-272oC. It shows poor solubility in polar and non polar solvents at room temperature but soluble in hot DMSO and DMF. Antifungal evaluation of the compound against a clinical isolate of the fungal strain Candida albican with a standard antifungal drug Terbinafine as a positive control demonstrate moderate inhibition of the growth of the organisms with a range of 18.0mm - 20.1mm.