Synthesis, Characterization and Antibacterial Studies of 4-{[(E)- Phenylmethylidene] amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide and its Mn(II) Complex

Abstract

A Schiff base, 4-{[(E)-Phenylmethylidene]amino}-N-(1,3-thiazol-2-yl)benzenesulfonamide (PTSA) was prepared by a reaction between benzaldehyde and sulphathiazole. Mn(II) complex of PTSA was also prepared. The melting point, colour, yield and conductivity of PTSA and [Mn(PTSA)] were determined. The PTSA and [Mn(PTSA)] were characterized by UV-Vis, FTIR and 1H-NMR spectroscopy. Low conductivity value of 13.9 Sm2mol^-1 indicated the non-electrolytic nature of the complex. The PTSA behaved as a tridentate ligand towards Mn, it coordinated through NH-group, two C=N groups. PTSA and [Mn(PTSA)] have been screened for their in vitro antibacterial activity against four bacterial strains; Staphylococcus aureus, Ecsherichia coli, Pseudomonas aeruginosa and Salmonella typhi. It was observed that the complex was more potent than PTSA against the bacterial strains used. In line with the findings, PTSA and [Mn(PTSA)] inhibited E. coli, P. aerugunosa, S. typhi and S. aureus. The Mn(II) complex showed enhanced antibacterial activity when compared with PTSA. It was deduced that [Mn(PTSA)] complex have improved antibacterial activity than PTSA alone and it was evident that the overall potency of PTSA was enhanced on coordination with manganese ion.

Keywords: Antibacterial, Complex, Manganese, Schiff base, Spectroscopy